Utility of the 13C‐pantoprazole breath test as a CYP2C19 phenotyping probe for children
Abstract The 13C‐pantoprazole breath test (PAN‐BT) is a safe, noninvasive, in vivo CYP2C19 phenotyping probe for adults. Our objective was to evaluate PAN‐BT performance in children, with a focus on discriminating individuals who, according to guidelines from the Clinical Pharmacology Implementation...
Main Authors: | Keith Feldman, Gregory L. Kearns, Robin E. Pearce, Susan M. Abdel‐Rahman, James Steven Leeder, Alec Friesen, Vincent S. Staggs, Andrea Gaedigk, Jaylene Weigel, Valentina Shakhnovich |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2022-05-01
|
Series: | Clinical and Translational Science |
Online Access: | https://doi.org/10.1111/cts.13232 |
Similar Items
-
A longitudinal study of cytochrome P450 2D6 (CYP2D6) activity during adolescence
by: J. Steven Leeder, et al.
Published: (2022-10-01) -
How to Conduct Clinical Trials in Children: A Tutorial
by: Valentina Shakhnovich, et al.
Published: (2019-05-01) -
CYP2D7 sequence variation interferes with TaqMan CYP2D6*15 and *35 genotyping
by: Amanda K Riffel, et al.
Published: (2016-01-01) -
Environmentally Benign and Facile Process for the Synthesis of Pantoprazole Sodium Sesquihydrate: Phase Transformation of Pantoprazole Sodium Heterosolvate to Pantoprazole Sodium Sesquihydrate
by: Arun Kumar Awasthi, et al.
Published: (2017-09-01) -
Impact of SLCO1B1 Genetic Variation on Rosuvastatin Systemic Exposure in Pediatric Hypercholesterolemia
by: Jonathan B. Wagner, et al.
Published: (2020-05-01)