Exosomal lncRNA UCA1 Derived From Pancreatic Stellate Cells Promotes Gemcitabine Resistance in Pancreatic Cancer via the SOCS3/EZH2 Axis

Exosomal lncRNA UCA1 Derived From Pancreatic Stellate Cells Promotes Gemcitabine Resistance in Pancreatic Cancer via the SOCS3/EZH2 Axis

ObjectivePancreatic cancer is associated with poor prognosis and dismal survival rates. This study aims to investigate roles of lncRNA UCA1-loaded exosomes secreted by pancreatic stellate cells (PSCs) in Gemcitabine (Gem) resistance of pancreatic cancer under hypoxia, which involves the methylation...

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Bibliographic Details
Main Authors: Yuan Chi, He Xin, Zhaoyu Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Oncology
Subjects:
pancreatic cancer
hypoxia
pancreatic stellate cells
exosomes
lncRNA UCA1
gemcitabine resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.671082/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.671082/full

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