VEGF-A/Notch-Induced Podosomes Proteolyse Basement Membrane Collagen-IV during Retinal Sprouting Angiogenesis

VEGF-A/Notch-Induced Podosomes Proteolyse Basement Membrane Collagen-IV during Retinal Sprouting Angiogenesis

During angiogenic sprouting, endothelial tip cells emerge from existing vessels in a process that requires vascular basement membrane degradation. Here, we show that F-actin/cortactin/P-Src-based matrix-degrading microdomains called podosomes contribute to this step. In vitro, VEGF-A/Notch signaling...

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Bibliographic Details
Main Authors: Pirjo Spuul, Thomas Daubon, Bettina Pitter, Florian Alonso, Isabelle Fremaux, IJsbrand Kramer, Eloi Montanez, Elisabeth Génot
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
cytoskeleton
actin
VEGF-A
Notch/Dll4 signaling
podosomes
tip cells
angiogenesis
retina
basement membrane
collagen-IV
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716312384

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http://www.sciencedirect.com/science/article/pii/S2211124716312384

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