A mouse strain defective in both T cells and NK cells has enhanced sensitivity to tumor induction by plasmid DNA expressing both activated H-Ras and c-Myc.

A mouse strain defective in both T cells and NK cells has enhanced sensitivity to tumor induction by plasmid DNA expressing both activated H-Ras and c-Myc.

As part of safety studies to evaluate the risk of residual cellular DNA in vaccines manufactured in tumorigenic cells, we have been developing in vivo assays to detect and quantify the oncogenic activity of DNA. We generated a plasmid expressing both an activated human H-ras gene and murine c-myc ge...

Full description

Bibliographic Details
Main Authors: Li Sheng-Fowler, Wei Tu, Haiqing Fu, Haruhiko Murata, Lynda Lanning, Gideon Foseh, Juliete Macauley, Donald Blair, Stephen H Hughes, John M Coffin, Andrew M Lewis, Keith Peden
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4193875?pdf=render

Internet

http://europepmc.org/articles/PMC4193875?pdf=render

Similar Items