Molecular Signatures of Response to Mecasermin in Children With Rett Syndrome

Molecular Signatures of Response to Mecasermin in Children With Rett Syndrome

Rett syndrome (RTT) is a devastating neurodevelopmental disorder without effective treatments. Attempts at developing targetted therapies have been relatively unsuccessful, at least in part, because the genotypical and phenotypical variability of the disorder. Therefore, identification of biomarkers...

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Bibliographic Details
Main Authors: Stephen Shovlin, Chloe Delepine, Lindsay Swanson, Snow Bach, Mustafa Sahin, Mriganka Sur, Walter E. Kaufmann, Daniela Tropea
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Neuroscience
Subjects:
Rett syndrome
mecasermin
insulin-like growth factor 1 (IGF1)
methyl-CpG binding protein 2 (MECP2)
biomarker
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.868008/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2022.868008/full

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