Local inhibition of matrix metalloproteinases reduced M2 macrophage activity and impeded recovery in spinal cord transected rats after treatment with fibroblast growth factor-1 and nerve grafts

Local inhibition of matrix metalloproteinases reduced M2 macrophage activity and impeded recovery in spinal cord transected rats after treatment with fibroblast growth factor-1 and nerve grafts

Alternatively activated macrophages (M2 macrophages) promote central nervous system regeneration. Our previous study demonstrated that treatment with peripheral nerve grafts and fibroblast growth factor-1 recruited more M2 macrophages and improved partial functional recovery in spinal cord transecte...

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Bibliographic Details
Main Authors: Chuan-Wen Chiu, Wen-Hung Huang, Huai-Sheng Kuo, May-Jywan Tsai, Ching-Jung Chen, Meng-Jen Lee, Henrich Cheng
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Neural Regeneration Research
Subjects:
spinal cord injury; fibroblast growth factor-1; matrix metalloproteinase; GM6001; macrophage
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=8;spage=1447;epage=1454;aulast=Chiu

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=8;spage=1447;epage=1454;aulast=Chiu

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