Inhibition of microglia overactivation restores neuronal survival in a mouse model of CDKL5 deficiency disorder

Inhibition of microglia overactivation restores neuronal survival in a mouse model of CDKL5 deficiency disorder

Abstract Background CDKL5 deficiency disorder (CDD), a severe neurodevelopmental disorder characterized by early onset epilepsy, intellectual disability, and autistic features, is caused by mutations in the CDKL5 gene. Evidence in animal models of CDD showed that absence of CDKL5 negatively affects...

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Bibliographic Details
Main Authors: Giuseppe Galvani, Nicola Mottolese, Laura Gennaccaro, Manuela Loi, Giorgio Medici, Marianna Tassinari, Claudia Fuchs, Elisabetta Ciani, Stefania Trazzi
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Journal of Neuroinflammation
Subjects:
CDKL5
Neuroinflammation
Neuronal survival
Luteolin
Online Access:https://doi.org/10.1186/s12974-021-02204-0

Internet

https://doi.org/10.1186/s12974-021-02204-0

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