Downregulation of MTHFD2 Inhibits Proliferation and Enhances Chemosensitivity in Hepatocellular Carcinoma via PI3K/AKT Pathway

Downregulation of MTHFD2 Inhibits Proliferation and Enhances Chemosensitivity in Hepatocellular Carcinoma via PI3K/AKT Pathway

Background: Despite the substantial impact of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) on cancer progression, its significance in the regulation of hepatocellular carcinoma (HCC) cell proliferation and chemosensitivity remains poorly defined. Methods: We evaluated MTHFD2 expression in a to...

Full description

Bibliographic Details
Main Authors: Jie Wang, Ze Yu, Yixiao Jiang, Ting Le, Yixin Wu, Ziqi Li, Guoqiang Zhang, Feiyue Wu, Haijie Ma
Format: Article
Language:English
Published: IMR Press 2024-01-01
Series:Frontiers in Bioscience-Landmark
Subjects:
mthfd2
proliferation
chemosensitivity
hcc
ki-67
Online Access:https://www.imrpress.com/journal/FBL/29/1/10.31083/j.fbl2901035

Internet

https://www.imrpress.com/journal/FBL/29/1/10.31083/j.fbl2901035

Similar Items