Influence of the Hypoxia-Activated Prodrug Evofosfamide (TH-302) on Glycolytic Metabolism of Canine Glioma: A Potential Improvement in Cancer Metabolism

Influence of the Hypoxia-Activated Prodrug Evofosfamide (TH-302) on Glycolytic Metabolism of Canine Glioma: A Potential Improvement in Cancer Metabolism

The transcription factor hypoxia-inducible factor 1α (HIF-1α) drives metabolic reprogramming in gliomas (GLs) under hypoxic conditions, promoting glycolysis for tumor development. Evofosfamide (EVO) releases a DNA-alkylating agent within hypoxic regions, indicating that it may serve as a hypoxia-tar...

Full description

Bibliographic Details
Main Authors: Hiroki Yamazaki, Seio Onoyama, Shunichi Gotani, Tatsuya Deguchi, Masahiro Tamura, Hiroshi Ohta, Hidetomo Iwano, Hidetaka Nishida, Peter J. Dickinson, Hideo Akiyoshi
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cancers
Subjects:
HIF-1α
evofosfamide
glycolysis
glioma
dogs
Online Access:https://www.mdpi.com/2072-6694/15/23/5537

Internet

https://www.mdpi.com/2072-6694/15/23/5537

Similar Items