Intracellular S100A9 Promotes Myeloid-Derived Suppressor Cells during Late Sepsis

Intracellular S100A9 Promotes Myeloid-Derived Suppressor Cells during Late Sepsis

Myeloid precursor cell reprogramming into a myeloid-derived suppressor cell (MDSC) contributes to high mortality rates in mouse and human sepsis. S100A9 mRNA and intracellular protein levels increase during early sepsis and remain elevated in Gr1+CD11b+ MDSCs after pro-inflammatory sepsis transition...

Full description

Bibliographic Details
Main Authors: Jun Dai, Ajinkya Kumbhare, Dima Youssef, Charles E. McCall, Mohamed El Gazzar
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
sepsis
myeloid-derived suppressor cells
immune suppression
S100A9
myeloid cell reprogramming
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01565/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01565/full

Similar Items