Exploring new structural features of the 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzenesulphonamide scaffold for the inhibition of human carbonic anhydrases

Exploring new structural features of the 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzenesulphonamide scaffold for the inhibition of human carbonic anhydrases

A library of 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulphonamides (EMAC8002a–m) was designed and synthesised to evaluate the effect of substituents in the positions 3 and 4 of the dihydrothiazole ring on the inhibitory potency and selectivity toward human carbonic anhy...

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Bibliographic Details
Main Authors: Simona Distinto, Rita Meleddu, Francesco Ortuso, Filippo Cottiglia, Serenella Deplano, Lisa Sequeira, Claudia Melis, Benedetta Fois, Andrea Angeli, Clemente Capasso, Rossella Angius, Stefano Alcaro, Claudiu T. Supuran, Elias Maccioni
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
antitumour agents
carbonic anhydrase inhibitors
dihydrotiazoles
sulphonamide
Online Access:http://dx.doi.org/10.1080/14756366.2019.1654470

Internet

http://dx.doi.org/10.1080/14756366.2019.1654470

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