HtrA1L364P leads to cognitive dysfunction and vascular destruction through TGF‐β/Smad signaling pathway in CARASIL model mice

HtrA1L364P leads to cognitive dysfunction and vascular destruction through TGF‐β/Smad signaling pathway in CARASIL model mice

Abstract Aims Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is a life‐threatening, inherited, nonhypertensive arteriole disease of the brain. Therapeutic strategy for CARASIL is limited because its pathogenesis is not clear. We previously repor...

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Bibliographic Details
Main Authors: Li Chuanfen, Wang Xiaoling, Jing Wen, Cao Bingzhen, Wang Min
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:Brain and Behavior
Subjects:
CARASIL
Mut‐HtrA1L364P mice
pathogenic mechanism
phenotypic analysis
Online Access:https://doi.org/10.1002/brb3.2691

Internet

https://doi.org/10.1002/brb3.2691

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