Endogenous Retrovirus-Derived Long Noncoding RNA Enhances Innate Immune Responses via Derepressing RELA Expression

Endogenous Retrovirus-Derived Long Noncoding RNA Enhances Innate Immune Responses via Derepressing RELA Expression

ABSTRACT Endogenous retroviruses (ERVs) are transposable elements that cause host genome instability and usually play deleterious roles in disease such as tumorigenesis. Recent advances also suggest that this “enemy within” may encode a viral mimic to induce antiviral immune responses through viral...

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Bibliographic Details
Main Authors: Bin Zhou, Fei Qi, Fangyi Wu, Hongbo Nie, Yifan Song, Lu Shao, Jingxuan Han, Zhen Wu, Hexige Saiyin, Gang Wei, Penghua Wang, Ting Ni, Feng Qian
Format: Article
Language:English
Published: American Society for Microbiology 2019-08-01
Series:mBio
Subjects:
NF-κB
antiviral immune responses
endogenous retroviruses
gene regulation
lncRNA
Online Access:https://journals.asm.org/doi/10.1128/mBio.00937-19

Internet

https://journals.asm.org/doi/10.1128/mBio.00937-19

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