Spatial transcriptomics of the lacrimal gland features macrophage activity and epithelium metabolism as key alterations during chronic inflammation

Spatial transcriptomics of the lacrimal gland features macrophage activity and epithelium metabolism as key alterations during chronic inflammation

The lacrimal gland (LG) is an exocrine gland that produces the watery part of the tear film that lubricates the ocular surface. Chronic inflammation, such as Sjögren’s syndrome (SS), is one of the leading causes of aqueous-deficiency dry eye (ADDE) disease worldwide. In this study we analyzed the ch...

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Bibliographic Details
Main Authors: Olivier Mauduit, Vanessa Delcroix, Takeshi Umazume, Cintia S. de Paiva, Darlene A. Dartt, Helen P. Makarenkova
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
lacrimal gland
chronic inflammation
visium
lipid metabolism
RNA sequencing
TYROBP
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1011125/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1011125/full

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