Caspase-1 Inhibitor Reduces Pyroptosis Induced by Brain Death in Kidney

Caspase-1 Inhibitor Reduces Pyroptosis Induced by Brain Death in Kidney

Brain death (BD) induces an organ-level inflammatory response. However, the underlying mechanisms have not been fully elucidated. Here, we investigated the role of caspase-1-mediated pyroptosis in BD-induced kidney injury in rats. A BD model was established in Sprague-Dawley rats. The rats were intr...

Full description

Bibliographic Details
Main Authors: Weifeng Liu, Dongjing Yang, Jihua Shi, Peihao Wen, Jiakai Zhang, Zhihui Wang, Bowen Hu, Xiaoyi Shi, Shengli Cao, Wenzhi Guo, Shuijun Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Surgery
Subjects:
brain death
renal injury
pyroptosis
caspase-1
caspase-11
hypoxia
Online Access:https://www.frontiersin.org/articles/10.3389/fsurg.2021.760989/full

Internet

https://www.frontiersin.org/articles/10.3389/fsurg.2021.760989/full

Similar Items