Nuclear Localization Leucine-Rich-Repeat Protein 1 Deficiency Protects Against Cardiac Hypertrophy by Pressure Overload

Nuclear Localization Leucine-Rich-Repeat Protein 1 Deficiency Protects Against Cardiac Hypertrophy by Pressure Overload

Background/Aims: Nuclear localization leucine-rich-repeat protein 1 (NLRP1) is a cytoplasmic protein, involved in autoimmune diseases, mammalian reproduction, neuronal cell death, and stroke. However, the role of NLRP1 in cardiac hypertrophy remains unclear. We used in vivo and in vitro models to in...

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Bibliographic Details
Main Authors: Jing Zong, Fang-fang Li, Kai Liang, Rui Dai, Hao Zhang, Ling Yan, Jia-li Liu, Lu-hong Xu, Wen-hao  Qian
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
NLRP1
Cardiac hypertrophy
Inflammation
Fibrosis
MAPK
NF-κB
Smad
Online Access:https://www.karger.com/Article/FullText/491664

Internet

https://www.karger.com/Article/FullText/491664

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