CD26 expression is attenuated by TGF‐β and SDF‐1 autocrine signaling on stromal myofibroblasts in human breast cancers

CD26 expression is attenuated by TGF‐β and SDF‐1 autocrine signaling on stromal myofibroblasts in human breast cancers

Abstract Human breast carcinoma‐associated fibroblasts (CAFs) increasingly acquire both transforming growth factor‐β (TGF‐β) and stromal cell‐derived factor‐1 (SDF‐1) signaling in an autocrine fashion during tumor progression. Such signaling mediates activated myofibroblastic and tumor‐promoting pro...

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Bibliographic Details
Main Authors: Yoshihiro Mezawa, Yataro Daigo, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Chikao Morimoto, Okio Hino, Akira Orimo
Format: Article
Language:English
Published: Wiley 2019-07-01
Series:Cancer Medicine
Subjects:
breast cancer
dipeptidyl peptidase 4
myofibroblasts
stromal cell‐derived factor 1
TGF‐beta
Online Access:https://doi.org/10.1002/cam4.2249

Internet

https://doi.org/10.1002/cam4.2249

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