Magnetic vagus nerve stimulation alleviates myocardial ischemia-reperfusion injury by the inhibition of pyroptosis through the M2AChR/OGDHL/ROS axis in rats
Abstract Background Myocardial ischemia-reperfusion (I/R) injury is accompanied by an imbalance in the cardiac autonomic nervous system, characterized by over-activated sympathetic tone and reduced vagal nerve activity. In our preceding study, we pioneered the development of the magnetic vagus nerve...
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-023-02189-3 |
| _version_ | 1797556709040848896 |
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| author | Yao Lu Kaiyan Chen Wei Zhao Yan Hua Siyuan Bao Jian Zhang Tianyu Wu Gaoyuan Ge Yue Yu Jianfei Sun Fengxiang Zhang |
| author_facet | Yao Lu Kaiyan Chen Wei Zhao Yan Hua Siyuan Bao Jian Zhang Tianyu Wu Gaoyuan Ge Yue Yu Jianfei Sun Fengxiang Zhang |
| author_sort | Yao Lu |
| collection | DOAJ |
| description | Abstract Background Myocardial ischemia-reperfusion (I/R) injury is accompanied by an imbalance in the cardiac autonomic nervous system, characterized by over-activated sympathetic tone and reduced vagal nerve activity. In our preceding study, we pioneered the development of the magnetic vagus nerve stimulation (mVNS) system. This system showcased precise vagus nerve stimulation, demonstrating remarkable effectiveness and safety in treating myocardial infarction. However, it remains uncertain whether mVNS can mitigate myocardial I/R injury and its specific underlying mechanisms. In this study, we utilized a rat model of myocardial I/R injury to delve into the therapeutic potential of mVNS against this type of injury. Results Our findings revealed that mVNS treatment led to a reduction in myocardial infarct size, a decrease in ventricular fibrillation (VF) incidence and a curbing of inflammatory cytokine release. Mechanistically, mVNS demonstrated beneficial effects on myocardial I/R injury by inhibiting NLRP3-mediated pyroptosis through the M2AChR/OGDHL/ROS axis. Conclusions Collectively, these outcomes highlight the promising potential of mVNS as a treatment strategy for myocardial I/R injury. |
| first_indexed | 2024-03-10T17:05:44Z |
| format | Article |
| id | doaj.art-3cb82ca64527422b9a678354e8b7932b |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-03-10T17:05:44Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-3cb82ca64527422b9a678354e8b7932b2023-11-20T10:48:13ZengBMCJournal of Nanobiotechnology1477-31552023-11-0121111810.1186/s12951-023-02189-3Magnetic vagus nerve stimulation alleviates myocardial ischemia-reperfusion injury by the inhibition of pyroptosis through the M2AChR/OGDHL/ROS axis in ratsYao Lu0Kaiyan Chen1Wei Zhao2Yan Hua3Siyuan Bao4Jian Zhang5Tianyu Wu6Gaoyuan Ge7Yue Yu8Jianfei Sun9Fengxiang Zhang10Section of Pacing and Electrophysiology, Division of Cardiology, The First Affiliated Hospital of Nanjing Medical UniversitySection of Pacing and Electrophysiology, Division of Cardiology, The First Affiliated Hospital of Nanjing Medical UniversitySection of Pacing and Electrophysiology, Division of Cardiology, The First Affiliated Hospital of Nanjing Medical UniversitySection of Pacing and Electrophysiology, Division of Cardiology, The First Affiliated Hospital of Nanjing Medical UniversityThe State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory of Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast UniversityDepartment of Echocardiography, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Shanghai Institute of Medical Imaging, Fudan UniversitySection of Pacing and Electrophysiology, Division of Cardiology, The First Affiliated Hospital of Nanjing Medical UniversitySection of Pacing and Electrophysiology, Division of Cardiology, The First Affiliated Hospital of Nanjing Medical UniversitySection of Pacing and Electrophysiology, Division of Cardiology, The First Affiliated Hospital of Nanjing Medical UniversityThe State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory of Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast UniversitySection of Pacing and Electrophysiology, Division of Cardiology, The First Affiliated Hospital of Nanjing Medical UniversityAbstract Background Myocardial ischemia-reperfusion (I/R) injury is accompanied by an imbalance in the cardiac autonomic nervous system, characterized by over-activated sympathetic tone and reduced vagal nerve activity. In our preceding study, we pioneered the development of the magnetic vagus nerve stimulation (mVNS) system. This system showcased precise vagus nerve stimulation, demonstrating remarkable effectiveness and safety in treating myocardial infarction. However, it remains uncertain whether mVNS can mitigate myocardial I/R injury and its specific underlying mechanisms. In this study, we utilized a rat model of myocardial I/R injury to delve into the therapeutic potential of mVNS against this type of injury. Results Our findings revealed that mVNS treatment led to a reduction in myocardial infarct size, a decrease in ventricular fibrillation (VF) incidence and a curbing of inflammatory cytokine release. Mechanistically, mVNS demonstrated beneficial effects on myocardial I/R injury by inhibiting NLRP3-mediated pyroptosis through the M2AChR/OGDHL/ROS axis. Conclusions Collectively, these outcomes highlight the promising potential of mVNS as a treatment strategy for myocardial I/R injury.https://doi.org/10.1186/s12951-023-02189-3Myocardial I/R injuryVagus nervemVNSPyroptosisOGDHL |
| spellingShingle | Yao Lu Kaiyan Chen Wei Zhao Yan Hua Siyuan Bao Jian Zhang Tianyu Wu Gaoyuan Ge Yue Yu Jianfei Sun Fengxiang Zhang Magnetic vagus nerve stimulation alleviates myocardial ischemia-reperfusion injury by the inhibition of pyroptosis through the M2AChR/OGDHL/ROS axis in rats Journal of Nanobiotechnology Myocardial I/R injury Vagus nerve mVNS Pyroptosis OGDHL |
| title | Magnetic vagus nerve stimulation alleviates myocardial ischemia-reperfusion injury by the inhibition of pyroptosis through the M2AChR/OGDHL/ROS axis in rats |
| title_full | Magnetic vagus nerve stimulation alleviates myocardial ischemia-reperfusion injury by the inhibition of pyroptosis through the M2AChR/OGDHL/ROS axis in rats |
| title_fullStr | Magnetic vagus nerve stimulation alleviates myocardial ischemia-reperfusion injury by the inhibition of pyroptosis through the M2AChR/OGDHL/ROS axis in rats |
| title_full_unstemmed | Magnetic vagus nerve stimulation alleviates myocardial ischemia-reperfusion injury by the inhibition of pyroptosis through the M2AChR/OGDHL/ROS axis in rats |
| title_short | Magnetic vagus nerve stimulation alleviates myocardial ischemia-reperfusion injury by the inhibition of pyroptosis through the M2AChR/OGDHL/ROS axis in rats |
| title_sort | magnetic vagus nerve stimulation alleviates myocardial ischemia reperfusion injury by the inhibition of pyroptosis through the m2achr ogdhl ros axis in rats |
| topic | Myocardial I/R injury Vagus nerve mVNS Pyroptosis OGDHL |
| url | https://doi.org/10.1186/s12951-023-02189-3 |
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