Straightforward Synthesis of 2(5H)-Furanones as Promising Cross-Coupling Partners: Direct Furanone Annulation Utilizing Ti-Mediated Aldol Addition

Straightforward Synthesis of 2(5H)-Furanones as Promising Cross-Coupling Partners: Direct Furanone Annulation Utilizing Ti-Mediated Aldol Addition

Direct 2(5H)-furanone annulation produces promising cross-coupling partners incorporating m- or p-bromo- and p-tosyloxyphenyl groups into the 5-position of a notable 2(5H)-furanone pharmacore. The present one-pot annulation method involves two distinctive reactions: (i) a powerful and crossed Ti-dir...

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Bibliographic Details
Main Authors: Yuki Ban, Yuichiro Ashida, Hidefumi Nakatsuji, Yoo Tanabe
Format: Article
Language:English
Published: MDPI AG 2016-09-01
Series:Molbank
Subjects:
Cross-aldol reaction
titanium chloride
furanone
furanone annulation
Ti-mediated reaction
1,1-dimethoxyacetone
bromophenyl ketone
tosyloxy ketone
cross-coupling partner
Suzuki-Miyaura cross-coupling
Online Access:http://www.mdpi.com/1422-8599/2016/4/M908

Internet

http://www.mdpi.com/1422-8599/2016/4/M908

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