Preparation of Antiproliferative Terpene-Alkaloid Hybrids by Free Radical-Mediated Modification of <i>ent</i>-Kauranic Derivatives

Preparation of Antiproliferative Terpene-Alkaloid Hybrids by Free Radical-Mediated Modification of <i>ent</i>-Kauranic Derivatives

A convenient strategy for molecular editing of available <i>ent</i>-kauranic natural scaffolds has been developed based on radical mediated C–C bond formation. Iodine atom transfer radical addition (ATRA) followed by rapid ionic elimination and radical azidoalkylation were investigated....

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Bibliographic Details
Main Authors: Elena Pruteanu, Vladilena Gîrbu, Nicon Ungur, Leentje Persoons, Dirk Daelemans, Philippe Renaud, Veaceslav Kulcițki
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Molecules
Subjects:
diterpene
<i>ent</i>-kaurane
alkaloids
radical chemistry
ATRA
lactam
Online Access:https://www.mdpi.com/1420-3049/26/15/4549

Internet

https://www.mdpi.com/1420-3049/26/15/4549

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