Hedgehog Pathway Inhibition by Novel Small Molecules Impairs Melanoma Cell Migration and Invasion under Hypoxia

Hedgehog Pathway Inhibition by Novel Small Molecules Impairs Melanoma Cell Migration and Invasion under Hypoxia

Melanoma is the principal cause of death in skin cancer due to its ability to invade and cause metastasis. Hypoxia, which characterises the tumour microenvironment (TME), plays an important role in melanoma development, as cancer cells can adapt and acquire a more aggressive phenotype. Carbonic anhy...

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Bibliographic Details
Main Authors: Alessandro Falsini, Gaia Giuntini, Mattia Mori, Francesca Ghirga, Deborah Quaglio, Antonino Cucinotta, Federica Coppola, Irene Filippi, Antonella Naldini, Bruno Botta, Fabio Carraro
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Pharmaceuticals
Subjects:
hypoxia
Hedgehog pathway
carbonic anhydrases
chemical compounds
Online Access:https://www.mdpi.com/1424-8247/17/2/227

Internet

https://www.mdpi.com/1424-8247/17/2/227

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