4-Phenylbutyrate ameliorates apoptotic neural cell death in Down syndrome by reducing protein aggregates

4-Phenylbutyrate ameliorates apoptotic neural cell death in Down syndrome by reducing protein aggregates

Abstract Individuals with Down syndrome (DS) commonly show unique pathological phenotypes throughout their life span. Besides the specific effects of dosage-sensitive genes on chromosome 21, recent studies have demonstrated that the gain of a chromosome exerts an adverse impact on cell physiology, r...

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Bibliographic Details
Main Authors: Katsuya Hirata, Toshihiko Nambara, Keiji Kawatani, Nobutoshi Nawa, Hidetaka Yoshimatsu, Haruna Kusakabe, Kimihiko Banno, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Hidetoshi Taniguchi, Hitomi Arahori, Kazuko Wada, Keiichi Ozono, Yasuji Kitabatake
Format: Article
Language:English
Published: Nature Portfolio 2020-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-70362-x

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https://doi.org/10.1038/s41598-020-70362-x

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