The Xbp1-regulated transcription factor Mist1 restricts antibody secretion by restraining Blimp1 expression in plasma cells

The Xbp1-regulated transcription factor Mist1 restricts antibody secretion by restraining Blimp1 expression in plasma cells

Antibody secretion by plasma cells provides acute and long-term protection against pathogens. The high secretion potential of plasma cells depends on the unfolded protein response, which is controlled by the transcription factor Xbp1. Here, we analyzed the Xbp1-dependent gene expression program of p...

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Bibliographic Details
Main Authors: Miriam Wöhner, Theresa Pinter, Peter Bönelt, Astrid Hagelkruys, Daniela Kostanova-Poliakova, Johannes Stadlmann, Stephen F. Konieczny, Maria Fischer, Markus Jaritz, Meinrad Busslinger
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
Mist1 (Bhlha15)
Blimp1 (Prdm1)
XBP1
plasma cell differentiation
antibody secretion
unfolded protein response (UPR)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.859598/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.859598/full

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