A Puzzling Protein from <i>Variovorax paradoxus</i> Has a PLP Fold Type IV Transaminase Structure and Binds PLP without Catalytic Lysine

A Puzzling Protein from <i>Variovorax paradoxus</i> Has a PLP Fold Type IV Transaminase Structure and Binds PLP without Catalytic Lysine

Effective biocatalysts for the synthesis of optically pure amines from keto precursors are highly required in organic synthesis. Transaminases are a large group of PLP-dependent enzymes, which can be utilized for production of chiral amines or amino acids. The bioinformatic approach previously made...

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Bibliographic Details
Main Authors: Konstantin M. Boyko, Ilya O. Matyuta, Alena Y. Nikolaeva, Tatiana V. Rakitina, Vladimir O. Popov, Ekaterina Yu. Bezsudnova, Maria G. Khrenova
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Crystals
Subjects:
BCAT
transaminase
crystal structure
molecular dynamics
<i>Variovorax paradoxus</i>
aminotransferase-like protein
Online Access:https://www.mdpi.com/2073-4352/12/5/619

Internet

https://www.mdpi.com/2073-4352/12/5/619

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