Simple and Expedient Access to Novel Fluorinated Thiazolo- and Oxazolo[3,2-<i>a</i>]pyrimidin-7-one Derivatives and Their Functionalization via Palladium-Catalyzed Reactions

Simple and Expedient Access to Novel Fluorinated Thiazolo- and Oxazolo[3,2-<i>a</i>]pyrimidin-7-one Derivatives and Their Functionalization via Palladium-Catalyzed Reactions

An efficient, versatile, and one-pot method for the preparation of novel fluorinated thiazolo- and oxazolo[3,2-<i>a</i>]pyrimidin-7-ones is described from 2-aminothiazoles or 2-amino-oxazoles and fluorinated alkynoates. This transformation, performed under transition-metal-free condition...

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Bibliographic Details
Main Authors: Wafa Blancou, Badr Jismy, Soufiane Touil, Hassan Allouchi, Mohamed Abarbri
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Molecules
Subjects:
thiazolo[3,2-<i>a</i>]pyrimidin-7-ones
oxazolo[3,2-<i>a</i>]pyrimidin-7-ones
fluorinated alkynes
regioselective
one-pot reaction
Suzuki-Miyaura
Online Access:https://www.mdpi.com/1420-3049/27/9/3013

Internet

https://www.mdpi.com/1420-3049/27/9/3013

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