MCP-1 impacts RCT by repressing ABCA1, ABCG1, and SR-BI through PI3K/Akt posttranslational regulation in HepG2 cells[S]

MCP-1 impacts RCT by repressing ABCA1, ABCG1, and SR-BI through PI3K/Akt posttranslational regulation in HepG2 cells[S]

Monocyte chemoattractant protein-1 (MCP-1) plays crucial roles at multiple stages of atherosclerosis. We hypothesized that MCP-1 might impair the reverse cholesterol transport (RCT) capacity of HepG2 cells by decreasing the cell-surface protein expression of ATP binding cassette A1 (ABCA1), ATP bind...

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Bibliographic Details
Main Authors: Can-Xia Huang, Yu-Ling Zhang, Jing-Feng Wang, Jie-Yu Jiang, Jin-Lan Bao
Format: Article
Language:English
Published: Elsevier 2013-05-01
Series:Journal of Lipid Research
Subjects:
monocyte chemoattractant protein -1
reverse cholesterol transport
HepG2 cells
high density lipoprotein
phosphoinositide 3-kinase/Akt pathway
ATP binding cassette A1
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520421625

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http://www.sciencedirect.com/science/article/pii/S0022227520421625

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