Joint pre-processing framework for two-dimensional gel electrophoresis images based on nonlinear filtering, background correction and normalization techniques

Joint pre-processing framework for two-dimensional gel electrophoresis images based on nonlinear filtering, background correction and normalization techniques

Abstract Background Two-dimensional gel electrophoresis (2-DGE) is a commonly used tool for proteomic analysis. This gel-based technique separates proteins in a sample according to their isoelectric point and molecular weight. 2-DGE images often present anomalies due to the acquisition process, such...

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Bibliographic Details
Main Authors: Manuel Mauricio Goez, Maria C. Torres-Madronero, Sarah Rothlisberger, Edilson Delgado-Trejos
Format: Article
Language:English
Published: BMC 2020-08-01
Series:BMC Bioinformatics
Subjects:
Adaptive histogram equalization
Multilevel thresholding
Nonlinear diffusion
Pre-processing
Two-dimensional gel electrophoresis
Online Access:http://link.springer.com/article/10.1186/s12859-020-03713-0

Internet

http://link.springer.com/article/10.1186/s12859-020-03713-0

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