Design, synthesis, and antitumor efficacy of novel 5-deazaflavin derivatives backed by kinase screening, docking, and ADME studies

Design, synthesis, and antitumor efficacy of novel 5-deazaflavin derivatives backed by kinase screening, docking, and ADME studies

AbstractNovel 5-deazaflavins were designed as potential anticancer candidates. Compounds 4j, 4k, 5b, 5i, and 9f demonstrated high cytotoxicity against MCF-7 cell line with IC50 of 0.5–190nM. Compounds 8c and 9g showed preferential activity against Hela cells (IC50: 1.69 and 1.52 μM respectively). Ho...

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Bibliographic Details
Main Authors: Walaa A. Bedewy, Mosaad S. Mohamed, Ahmed M. Abdelhameed, Mohamed A. Elsawy, Mohammed Al-Muhur, Noriyuki Ashida, Ashraf N Abdalla, Tamer A. Elwaie, Tomohisa Nagamatsu, Hamed I. Ali
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
5-Deazaflavin
antitumor
molecular docking
kinase profiling
ADME
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2023.2220570

Internet

https://www.tandfonline.com/doi/10.1080/14756366.2023.2220570

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