EZH2-H3K27me3 mediated KRT14 upregulation promotes TNBC peritoneal metastasis
Enhancer of zeste homolog 2 (EZH2) has been associated with poor prognosis in triple negative breast cancer (TNBC). Here, the authors suggest a potential role for trimethylation function of EZH2 in driving peritoneal metastasis in TNBC.
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35059-x |
| _version_ | 1811315027968262144 |
|---|---|
| author | Ayushi Verma Akhilesh Singh Manish Pratap Singh Mushtaq Ahmad Nengroo Krishan Kumar Saini Saumya Ranjan Satrusal Muqtada Ali Khan Priyank Chaturvedi Abhipsa Sinha Sanjeev Meena Anup Kumar Singh Dipak Datta |
| author_facet | Ayushi Verma Akhilesh Singh Manish Pratap Singh Mushtaq Ahmad Nengroo Krishan Kumar Saini Saumya Ranjan Satrusal Muqtada Ali Khan Priyank Chaturvedi Abhipsa Sinha Sanjeev Meena Anup Kumar Singh Dipak Datta |
| author_sort | Ayushi Verma |
| collection | DOAJ |
| description | Enhancer of zeste homolog 2 (EZH2) has been associated with poor prognosis in triple negative breast cancer (TNBC). Here, the authors suggest a potential role for trimethylation function of EZH2 in driving peritoneal metastasis in TNBC. |
| first_indexed | 2024-04-13T11:22:55Z |
| format | Article |
| id | doaj.art-3ccd482811aa4e0e80f0a948c9c2ea58 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T11:22:55Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3ccd482811aa4e0e80f0a948c9c2ea582022-12-22T02:48:46ZengNature PortfolioNature Communications2041-17232022-11-0113112210.1038/s41467-022-35059-xEZH2-H3K27me3 mediated KRT14 upregulation promotes TNBC peritoneal metastasisAyushi Verma0Akhilesh Singh1Manish Pratap Singh2Mushtaq Ahmad Nengroo3Krishan Kumar Saini4Saumya Ranjan Satrusal5Muqtada Ali Khan6Priyank Chaturvedi7Abhipsa Sinha8Sanjeev Meena9Anup Kumar Singh10Dipak Datta11Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI)Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI)Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI)Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI)Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI)Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI)Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI)Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI)Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI)Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI)Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI)Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI)Enhancer of zeste homolog 2 (EZH2) has been associated with poor prognosis in triple negative breast cancer (TNBC). Here, the authors suggest a potential role for trimethylation function of EZH2 in driving peritoneal metastasis in TNBC.https://doi.org/10.1038/s41467-022-35059-x |
| spellingShingle | Ayushi Verma Akhilesh Singh Manish Pratap Singh Mushtaq Ahmad Nengroo Krishan Kumar Saini Saumya Ranjan Satrusal Muqtada Ali Khan Priyank Chaturvedi Abhipsa Sinha Sanjeev Meena Anup Kumar Singh Dipak Datta EZH2-H3K27me3 mediated KRT14 upregulation promotes TNBC peritoneal metastasis Nature Communications |
| title | EZH2-H3K27me3 mediated KRT14 upregulation promotes TNBC peritoneal metastasis |
| title_full | EZH2-H3K27me3 mediated KRT14 upregulation promotes TNBC peritoneal metastasis |
| title_fullStr | EZH2-H3K27me3 mediated KRT14 upregulation promotes TNBC peritoneal metastasis |
| title_full_unstemmed | EZH2-H3K27me3 mediated KRT14 upregulation promotes TNBC peritoneal metastasis |
| title_short | EZH2-H3K27me3 mediated KRT14 upregulation promotes TNBC peritoneal metastasis |
| title_sort | ezh2 h3k27me3 mediated krt14 upregulation promotes tnbc peritoneal metastasis |
| url | https://doi.org/10.1038/s41467-022-35059-x |
| work_keys_str_mv | AT ayushiverma ezh2h3k27me3mediatedkrt14upregulationpromotestnbcperitonealmetastasis AT akhileshsingh ezh2h3k27me3mediatedkrt14upregulationpromotestnbcperitonealmetastasis AT manishpratapsingh ezh2h3k27me3mediatedkrt14upregulationpromotestnbcperitonealmetastasis AT mushtaqahmadnengroo ezh2h3k27me3mediatedkrt14upregulationpromotestnbcperitonealmetastasis AT krishankumarsaini ezh2h3k27me3mediatedkrt14upregulationpromotestnbcperitonealmetastasis AT saumyaranjansatrusal ezh2h3k27me3mediatedkrt14upregulationpromotestnbcperitonealmetastasis AT muqtadaalikhan ezh2h3k27me3mediatedkrt14upregulationpromotestnbcperitonealmetastasis AT priyankchaturvedi ezh2h3k27me3mediatedkrt14upregulationpromotestnbcperitonealmetastasis AT abhipsasinha ezh2h3k27me3mediatedkrt14upregulationpromotestnbcperitonealmetastasis AT sanjeevmeena ezh2h3k27me3mediatedkrt14upregulationpromotestnbcperitonealmetastasis AT anupkumarsingh ezh2h3k27me3mediatedkrt14upregulationpromotestnbcperitonealmetastasis AT dipakdatta ezh2h3k27me3mediatedkrt14upregulationpromotestnbcperitonealmetastasis |