Mitochondrial genomic variation in dementia with Lewy bodies: association with disease risk and neuropathological measures

Mitochondrial genomic variation in dementia with Lewy bodies: association with disease risk and neuropathological measures

Abstract Dementia with Lewy bodies (DLB) is clinically diagnosed when patients develop dementia less than a year after parkinsonism onset. Age is the primary risk factor for DLB and mitochondrial health influences ageing through effective oxidative phosphorylation (OXPHOS). Patterns of stable polymo...

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Bibliographic Details
Main Authors: Rebecca R. Valentino, Chloe Ramnarine, Michael G. Heckman, Patrick W. Johnson, Alexandra I. Soto-Beasley, Ronald L. Walton, Shunsuke Koga, Koji Kasanuki, Melissa E. Murray, Ryan J. Uitti, Julie A. Fields, Hugo Botha, Vijay K. Ramanan, Kejal Kantarci, Val J. Lowe, Clifford R. Jack, Nilufer Ertekin-Taner, Rodolfo Savica, Jonathan Graff-Radford, Ronald C. Petersen, Joseph E. Parisi, R. Ross Reichard, Neill R. Graff-Radford, Tanis J. Ferman, Bradley F. Boeve, Zbigniew K. Wszolek, Dennis W. Dickson, Owen A. Ross
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Acta Neuropathologica Communications
Subjects:
Dementia with Lewy-bodies
Lewy body disease
Mitochondrial DNA
Mitochondrial haplogroups
Neuropathology
Online Access:https://doi.org/10.1186/s40478-022-01399-4

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https://doi.org/10.1186/s40478-022-01399-4

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