Discovery-Based Proteomics Identify Skeletal Muscle Mitochondrial Alterations as an Early Metabolic Defect in a Mouse Model of β-Thalassemia

Discovery-Based Proteomics Identify Skeletal Muscle Mitochondrial Alterations as an Early Metabolic Defect in a Mouse Model of β-Thalassemia

Although metabolic complications are common in thalassemia patients, there is still an unmet need to better understand underlying mechanisms. We used unbiased global proteomics to reveal molecular differences between the th<sup>3/+</sup> mouse model of thalassemia and wild-type control a...

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Bibliographic Details
Main Authors: Patricia Reboucas, Carine Fillebeen, Amy Botta, Riley Cleverdon, Alexandra P. Steele, Vincent Richard, René P. Zahedi, Christoph H. Borchers, Yan Burelle, Thomas J. Hawke, Kostas Pantopoulos, Gary Sweeney
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
thalassemia
iron
skeletal muscle
proteomics
mitochondria
Online Access:https://www.mdpi.com/1422-0067/24/5/4402

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https://www.mdpi.com/1422-0067/24/5/4402

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