Characterization of a novel type of HIV-1 particle assembly inhibitor using a quantitative luciferase-Vpr packaging-based assay.

Characterization of a novel type of HIV-1 particle assembly inhibitor using a quantitative luciferase-Vpr packaging-based assay.

The HIV-1 auxiliary protein Vpr and Vpr-fusion proteins can be copackaged with Gag precursor (Pr55Gag) into virions or membrane-enveloped virus-like particles (VLP). Taking advantage of this property, we developed a simple and sensitive method to evaluate potential inhibitors of HIV-1 assembly in a...

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Bibliographic Details
Main Authors: Gaëlle Gonzalez, Sandrina DaFonseca, Elisabeth Errazuriz, Pascale Coric, Florence Souquet, Serge Turcaud, Pierre Boulanger, Serge Bouaziz, Saw See Hong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3207847?pdf=render

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http://europepmc.org/articles/PMC3207847?pdf=render

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