Proof of concept for quantitative adverse outcome pathway modeling of chronic toxicity in repeated exposure

Proof of concept for quantitative adverse outcome pathway modeling of chronic toxicity in repeated exposure

Abstract Adverse Outcome Pathway (AOP) is a useful tool to glean mode of action (MOE) of a chemical. However, in order to use it for the purpose of risk assessment, an AOP needs to be quantified using in vitro or in vivo data. Majority of quantitative AOPs developed so far, were for single exposure...

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Bibliographic Details
Main Authors: Shigeaki Ito, Sayak Mukherjee, Kazuo Erami, Shugo Muratani, Akina Mori, Sakuya Ichikawa, William White, Kei Yoshino, Dawn Fallacara
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-55220-4

Internet

https://doi.org/10.1038/s41598-024-55220-4

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