Involvement of spinal G-protein inwardly rectifying potassium (GIRK) channels in the enhanced antinociceptive effects of the activation of both μ-opioid and cannabinoid CB1 receptors

Involvement of spinal G-protein inwardly rectifying potassium (GIRK) channels in the enhanced antinociceptive effects of the activation of both μ-opioid and cannabinoid CB1 receptors

Neuropathic pain is refractory to opioid analgesics. Since there are functional linkages between μ-opioid receptors (MOR) and cannabinoid receptors (CBR), the present study was designed to investigate the interactions between MOR and CB1R based on antinociceptive effects for neuropathic pain mediate...

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Bibliographic Details
Main Authors: Yoshinori Takemura, Yuka Sudo, Tomoya Saeki, Shinji Kurata, Tsutomu Suzuki, Tomohisa Mori, Yasuhito Uezono
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Journal of Pharmacological Sciences
Subjects:
μ-Opioid
Cannabinoid
G protein-coupled inwardly-rectifying potassium channels
Antinociceptive effect
Spinal cord
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861322000287

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http://www.sciencedirect.com/science/article/pii/S1347861322000287

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