The Proteome Signatures of Fibroblasts from Patients with Severe, Intermediate and Mild Spinal Muscular Atrophy Show Limited Overlap

The Proteome Signatures of Fibroblasts from Patients with Severe, Intermediate and Mild Spinal Muscular Atrophy Show Limited Overlap

Most research to characterise the molecular consequences of spinal muscular atrophy (SMA) has focused on SMA I. Here, proteomic profiling of skin fibroblasts from severe (SMA I), intermediate (SMA II), and mild (SMA III) patients, alongside age-matched controls, was conducted using SWATH mass spectr...

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Bibliographic Details
Main Authors: Sharon J. Brown, Rachel A. Kline, Silvia A. Synowsky, Sally L. Shirran, Ian Holt, Kelly A. Sillence, Peter Claus, Brunhilde Wirth, Thomas M. Wishart, Heidi R. Fuller
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
Spinal muscular atrophy
SMA
fibroblasts
severity
proteomics
biomarkers
Online Access:https://www.mdpi.com/2073-4409/11/17/2624

Internet

https://www.mdpi.com/2073-4409/11/17/2624

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