GRK3 is a poor prognosticator and serves as a therapeutic target in advanced gastric adenocarcinoma

GRK3 is a poor prognosticator and serves as a therapeutic target in advanced gastric adenocarcinoma

Abstract Background G protein-coupled receptor (GPCR) is the most targeted protein family by the FDA-approved drugs. GPCR-kinase 3 (GRK3) is critical for GPCR signaling. Our genomic analysis showed that GRK3 expression correlated with poor prognosis of gastric adenocarcinoma (GAC) patients. However,...

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Bibliographic Details
Main Authors: Yuan Li, Yibo Fan, Jinbang Xu, Longfei Huo, Ailing W. Scott, Jiankang Jin, Boxuan Yang, Shan Shao, Lang Ma, Ying Wang, Xiaodan Yao, Melissa Pool Pizzi, Matheus Sewastjanow Da Silva, Guoliang Zhang, Lijuan Zhuo, Eun Jeong Cho, Kevin N. Dalby, Namita D. Shanbhag, Zhenning Wang, Wenliang Li, Shumei Song, Jaffer A. Ajani
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Gastric adenocarcinoma
GRK3
Hippo/YAP1
Prognosis
Peritoneal metastases
Online Access:https://doi.org/10.1186/s13046-022-02463-6

Internet

https://doi.org/10.1186/s13046-022-02463-6

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