Disruption of CD47-SIRPα signaling restores inflammatory function in tumor-associated myeloid-derived suppressor cells

Disruption of CD47-SIRPα signaling restores inflammatory function in tumor-associated myeloid-derived suppressor cells

Summary: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous immune population with diverse immunosuppressive functions in solid tumors. Here, we explored the role of the tumor microenvironment in regulating MDSC differentiation and immunosuppressive properties via signal-regulatory protein...

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Bibliographic Details
Main Authors: Carlo Zimarino, William Moody, Sarah E. Davidson, Hafsa Munir, Jacqueline D. Shields
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:iScience
Subjects:
Molecular biology
Immunology
Cell biology
Stem cells research
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224007685

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http://www.sciencedirect.com/science/article/pii/S2589004224007685

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