Reovirus FAST Protein Enhances Vesicular Stomatitis Virus Oncolytic Virotherapy in Primary and Metastatic Tumor Models

Reovirus FAST Protein Enhances Vesicular Stomatitis Virus Oncolytic Virotherapy in Primary and Metastatic Tumor Models

The reovirus fusion-associated small transmembrane (FAST) proteins are the smallest known viral fusogens (∼100–150 amino acids) and efficiently induce cell-cell fusion and syncytium formation in multiple cell types. Syncytium formation enhances cell-cell virus transmission and may also induce immuno...

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Bibliographic Details
Main Authors: Fabrice Le Boeuf, Simon Gebremeskel, Nichole McMullen, Han He, Anna L. Greenshields, David W. Hoskin, John C. Bell, Brent Johnston, Chungen Pan, Roy Duncan
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Molecular Therapy: Oncolytics
Subjects:
oncolytic virotherapy
vesicular stomatitis virus
FAST protein
syncytium formation
4T1 mammary adenocarcinoma
CT26 colon carcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S237277051730030X

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http://www.sciencedirect.com/science/article/pii/S237277051730030X

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