Synthesis of 4-Aminopyrazol-5-ols as Edaravone Analogs and Their Antioxidant Activity

Synthesis of 4-Aminopyrazol-5-ols as Edaravone Analogs and Their Antioxidant Activity

One of the powerful antioxidants used clinically is Edaravone (EDA). We synthesized a series of new EDA analogs, 4-aminopyrazol-5-ol hydrochlorides, including polyfluoroalkyl derivatives, via the reduction of 4-hydroxyiminopyrazol-5-ones. The primary antioxidant activity of the compounds in comparis...

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Main Authors: Yanina V. Burgart, Galina F. Makhaeva, Olga P. Krasnykh, Sophia S. Borisevich, Natalia A. Agafonova, Nadezhda V. Kovaleva, Natalia P. Boltneva, Elena V. Rudakova, Evgeny V. Shchegolkov, Galina A. Triandafilova, Denis A. Gazizov, Olga G. Serebryakova, Maria V. Ulitko, Sergey L. Khursan, Victor I. Saloutin, Rudy J. Richardson
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Molecules
Subjects:
Edaravone
4-aminopyrazol-5-ols
4-hydroxyiminopyrazol-5-ones
antioxidants
antiradical and ferric reducing activity
quantum-chemical calculations
Online Access:https://www.mdpi.com/1420-3049/27/22/7722

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https://www.mdpi.com/1420-3049/27/22/7722

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