Synthesis and Bioactivity of Luffarin I

Synthesis and Bioactivity of Luffarin I

The first synthesis of Luffarin I, sesterterpenolide isolated from sponge Luffariella geometrica, has been accomplished from commercially available sclareol. The key strategy involved in this synthesis is the diastereoselective reduction of an intermediate ketone. Luffarin I against human solid tumo...

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Bibliographic Details
Main Authors: Aitor Urosa, Isidro S. Marcos, David Díez, Anna Lithgow, Gabriela B. Plata, José M. Padrón, Pilar Basabe
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:Marine Drugs
Subjects:
luffarin I
sclareol
diastereoselective reduction
sponges
sesterterpenolide
marine metabolites
Online Access:http://www.mdpi.com/1660-3397/13/4/2407

Internet

http://www.mdpi.com/1660-3397/13/4/2407

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