Polymorphisms in mTOR and Calcineurin Signaling Pathways Are Associated With Long-Term Clinical Outcomes in Kidney Transplant Recipients

Polymorphisms in mTOR and Calcineurin Signaling Pathways Are Associated With Long-Term Clinical Outcomes in Kidney Transplant Recipients

Monitoring of immunosuppressive drugs, such as calcineurin and mTOR inhibitors, is essential to avoid undesirable kidney transplant outcomes. Polymorphisms in pharmacokinetics-related genes have been associated with variability in blood levels of immunosuppressive drugs and adverse effects, but infl...

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Bibliographic Details
Main Authors: Antony Brayan Campos-Salazar, Fabiana Dalla Vecchia Genvigir, Claudia Rosso Felipe, Helio Tedesco-Silva, José Medina-Pestana, Gabriela Vieira Monteiro, Rodrigo de Gouveia Basso, Alvaro Cerda, Mario Hiroyuki Hirata, Rosario Dominguez Crespo Hirata
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
kidney transplant
immunosuppressive drugs
mTOR
calcineurin
FOXP3
pharmacogenetics
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01296/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01296/full

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