MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly

MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly

The glucose-sensing Mondo pathway regulates expression of metabolic genes in mammals. Here, we characterized its function in the zebrafish and revealed an unexpected role of this pathway in vertebrate embryonic development. We showed that knockdown of mondoa impaired the early morphogenetic movement...

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Bibliographic Details
Main Authors: Meltem Weger, Benjamin D Weger, Andrea Schink, Masanari Takamiya, Johannes Stegmaier, Cédric Gobet, Alice Parisi, Andrei Yu Kobitski, Jonas Mertes, Nils Krone, Uwe Strähle, Gerd Ulrich Nienhaus, Ralf Mikut, Frédéric Gachon, Philipp Gut, Thomas Dickmeis
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
metabolism
cholesterol
pregnenolone
microtubule
epiboly
carbohydrate response element
Online Access:https://elifesciences.org/articles/57068

Internet

https://elifesciences.org/articles/57068

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