Tet-dependent 5-hydroxymethyl-Cytosine modification of mRNA regulates axon guidance genes in Drosophila.

Tet-dependent 5-hydroxymethyl-Cytosine modification of mRNA regulates axon guidance genes in Drosophila.

Modifications of mRNA, especially methylation of adenosine, have recently drawn much attention. The much rarer modification, 5-hydroxymethylation of cytosine (5hmC), is not well understood and is the subject of this study. Vertebrate Tet proteins are 5-methylcytosine (5mC) hydroxylases and catalyze...

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Bibliographic Details
Main Authors: Badri Nath Singh, Hiep Tran, Joseph Kramer, Elmira Kirichenko, Neha Changela, Fei Wang, Yaping Feng, Dibyendu Kumar, Min Tu, Jie Lan, Martin Bizet, François Fuks, Ruth Steward
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0293894

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https://doi.org/10.1371/journal.pone.0293894

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