Development and characterization of a prototypic pan-amyloid clearing agent – a novel murine peptide-immunoglobulin fusion

Development and characterization of a prototypic pan-amyloid clearing agent – a novel murine peptide-immunoglobulin fusion

IntroductionSystemic amyloidosis is a progressive disorder characterized by the extracellular deposition of amyloid fibrils and accessory proteins in visceral organs and tissues. Amyloid accumulation causes organ dysfunction and is not generally cleared by the immune system. Current treatment focuse...

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Bibliographic Details
Main Authors: James S. Foster, Manasi Balachandran, Trevor J. Hancock, Emily B. Martin, Sallie Macy, Craig Wooliver, Tina Richey, Alan Stuckey, Angela D. Williams, Joseph W. Jackson, Stephen J. Kennel, Jonathan S. Wall
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
systemic amyloidosis
amyloid phagocytosis
amyloid clearance
peptide p5
peptide-antibody fusion
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1275372/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1275372/full

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