Methotrexate-Loaded Solid Lipid Nanoparticles: Protein Functionalization to Improve Brain Biodistribution

Glioblastoma is the most common and invasive primary tumor of the central nervous system and normally has a negative prognosis. Biodistribution in healthy animal models is an important preliminary study aimed at investigating the efficacy of chemotherapy, as it is mainly addressed towards residual c...

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Bibliographic Details
Main Authors: Elisabetta Muntoni, Katia Martina, Elisabetta Marini, Marta Giorgis, Loretta Lazzarato, Iris Chiara Salaroglio, Chiara Riganti, Michele Lanotte, Luigi Battaglia
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Pharmaceutics
Subjects:
Online Access:https://www.mdpi.com/1999-4923/11/2/65