Targeting aurora kinases limits tumour growth through DNA damage‐mediated senescence and blockade of NF‐κB impairs this drug‐induced senescence

Targeting aurora kinases limits tumour growth through DNA damage‐mediated senescence and blockade of NF‐κB impairs this drug‐induced senescence

Abstract Oncogene‐induced senescence can provide a protective mechanism against tumour progression. However, production of cytokines and growth factors by senescent cells may contribute to tumour development. Thus, it is unclear whether induction of senescence represents a viable therapeutic approac...

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Bibliographic Details
Main Authors: Yan Liu, Oriana E. Hawkins, Yingjun Su, Anna E. Vilgelm, Tammy Sobolik, Yee‐Mon Thu, Sara Kantrow, Ryan C. Splittgerber, Sarah Short, Katayoun I. Amiri, Jeffery A. Ecsedy, Jeffery A. Sosman, Mark C. Kelley, Ann Richmond
Format: Article
Language:English
Published: Springer Nature 2012-11-01
Series:EMBO Molecular Medicine
Subjects:
aurora kinase
DNA damage
melanoma
NF‐κB
senescence
Online Access:https://doi.org/10.1002/emmm.201201378

Internet

https://doi.org/10.1002/emmm.201201378

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