Synthetic lethal gene pairs: Experimental approaches and predictive models

Synthetic lethal gene pairs: Experimental approaches and predictive models

Synthetic lethality (SL) refers to a genetic interaction in which the simultaneous perturbation of two genes leads to cell or organism death, whereas viability is maintained when only one of the pair is altered. The experimental exploration of these pairs and predictive modeling in computational bio...

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Bibliographic Details
Main Authors: Shan Tang, Birkan Gökbağ, Kunjie Fan, Shuai Shao, Yang Huo, Xue Wu, Lijun Cheng, Lang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Genetics
Subjects:
synthetic lethality
gene–gene interaction
machine learning (ML)
computational biology
predictive model
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.961611/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.961611/full

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