Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging

Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging

Unlike aged somatic cells, which exhibit a decline in molecular fidelity and eventually reach a state of replicative senescence, pluripotent stem cells can indefinitely replenish themselves while retaining full homeostatic capacity. The conferment of beneficial-pluripotency related traits via in viv...

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Bibliographic Details
Main Authors: Patrick Treat Paine, Cheyenne Rechsteiner, Francesco Morandini, Gabriela Desdín-Micó, Calida Mrabti, Alberto Parras, Amin Haghani, Robert Brooke, Steve Horvath, Andrei Seluanov, Vera Gorbunova, Alejandro Ocampo
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Aging
Subjects:
aging
DNA damage
ercc1
cellular reprogramming
TGFb
Online Access:https://www.frontiersin.org/articles/10.3389/fragi.2023.1323194/full

Internet

https://www.frontiersin.org/articles/10.3389/fragi.2023.1323194/full

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