Pivotal role of Toll-like receptors 2 and 4, its adaptor molecule MyD88, and inflammasome complex in experimental tubule-interstitial nephritis.

Pivotal role of Toll-like receptors 2 and 4, its adaptor molecule MyD88, and inflammasome complex in experimental tubule-interstitial nephritis.

Tubule-interstitial nephritis (TIN) results in decreased renal function and interstitial inflammation, which ultimately leads to fibrosis. Excessive adenine intake can cause TIN because xanthine dehydrogenase (XDH) can convert this purine into an insoluble compound, which precipitates in the tubuli....

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Bibliographic Details
Main Authors: Matheus Correa-Costa, Tarcio Teodoro Braga, Patricia Semedo, Caroline Yuri Hayashida, Luiz Roberto Grassmann Bechara, Rosa Maria Elias, Claudiene Rodrigues Barreto, Claudia Silva-Cunha, Meire Ioshie Hyane, Giselle Martins Gonçalves, Patricia Chakur Brum, Clarice Fujihara, Roberto Zatz, Alvaro Pacheco-Silva, Dario S Zamboni, Niels Olsen Saraiva Camara
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3237574?pdf=render

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http://europepmc.org/articles/PMC3237574?pdf=render

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