Hormonal contraception alters vaginal microbiota and cytokines in South African adolescents in a randomized trial
Hormonal contraception may alter women’s susceptibility to HIV. Here, the authors report the results of a randomized clinical trial substudy assessing the effects of injectable Net-En, oral contraceptives (COC) and Nuvaring on vaginal microbiota and cytokines, associating COC with lower microbial di...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-11-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19382-9 |
| _version_ | 1818751615605145600 |
|---|---|
| author | Christina Balle Iyaloo N. Konstantinus Shameem Z. Jaumdally Enock Havyarimana Katie Lennard Rachel Esra Shaun L. Barnabas Anna-Ursula Happel Zoe Moodie Katherine Gill Tanya Pidwell Ulas Karaoz Eoin Brodie Venessa Maseko Hoyam Gamieldien Steven E. Bosinger Landon Myer Linda-Gail Bekker Jo-Ann S. Passmore Heather B. Jaspan |
| author_facet | Christina Balle Iyaloo N. Konstantinus Shameem Z. Jaumdally Enock Havyarimana Katie Lennard Rachel Esra Shaun L. Barnabas Anna-Ursula Happel Zoe Moodie Katherine Gill Tanya Pidwell Ulas Karaoz Eoin Brodie Venessa Maseko Hoyam Gamieldien Steven E. Bosinger Landon Myer Linda-Gail Bekker Jo-Ann S. Passmore Heather B. Jaspan |
| author_sort | Christina Balle |
| collection | DOAJ |
| description | Hormonal contraception may alter women’s susceptibility to HIV. Here, the authors report the results of a randomized clinical trial substudy assessing the effects of injectable Net-En, oral contraceptives (COC) and Nuvaring on vaginal microbiota and cytokines, associating COC with lower microbial diversity and Nuvaring with increased inflammation. |
| first_indexed | 2024-12-18T04:38:23Z |
| format | Article |
| id | doaj.art-3d0099497abb46188c654efca2cd2cb7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:38:23Z |
| publishDate | 2020-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3d0099497abb46188c654efca2cd2cb72022-12-21T21:20:47ZengNature PortfolioNature Communications2041-17232020-11-0111111510.1038/s41467-020-19382-9Hormonal contraception alters vaginal microbiota and cytokines in South African adolescents in a randomized trialChristina Balle0Iyaloo N. Konstantinus1Shameem Z. Jaumdally2Enock Havyarimana3Katie Lennard4Rachel Esra5Shaun L. Barnabas6Anna-Ursula Happel7Zoe Moodie8Katherine Gill9Tanya Pidwell10Ulas Karaoz11Eoin Brodie12Venessa Maseko13Hoyam Gamieldien14Steven E. Bosinger15Landon Myer16Linda-Gail Bekker17Jo-Ann S. Passmore18Heather B. Jaspan19Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape TownDepartment of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape TownDepartment of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape TownDepartment of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape TownDepartment of Integrative Biomedical Sciences, University of Cape TownDepartment of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape TownDepartment of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape TownDepartment of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape TownVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research CenterDesmond Tutu HIV Centre, University of Cape TownDesmond Tutu HIV Centre, University of Cape TownEarth and Environmental Science, Lawrence Berkeley National LaboratoriesEarth and Environmental Science, Lawrence Berkeley National LaboratoriesNational Institute for Communicable Diseases, SandringhamDepartment of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape TownDepartment of Pathology & Laboratory Medicine, Emory University School of Medicine; Division of Microbiology and Immunology, Yerkes National Primate Research CenterDivision of Epidemiology, Biostatistics, School of Public Health & Family Medicine, University of Cape TownDesmond Tutu HIV Centre, University of Cape TownDepartment of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape TownDepartment of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape TownHormonal contraception may alter women’s susceptibility to HIV. Here, the authors report the results of a randomized clinical trial substudy assessing the effects of injectable Net-En, oral contraceptives (COC) and Nuvaring on vaginal microbiota and cytokines, associating COC with lower microbial diversity and Nuvaring with increased inflammation.https://doi.org/10.1038/s41467-020-19382-9 |
| spellingShingle | Christina Balle Iyaloo N. Konstantinus Shameem Z. Jaumdally Enock Havyarimana Katie Lennard Rachel Esra Shaun L. Barnabas Anna-Ursula Happel Zoe Moodie Katherine Gill Tanya Pidwell Ulas Karaoz Eoin Brodie Venessa Maseko Hoyam Gamieldien Steven E. Bosinger Landon Myer Linda-Gail Bekker Jo-Ann S. Passmore Heather B. Jaspan Hormonal contraception alters vaginal microbiota and cytokines in South African adolescents in a randomized trial Nature Communications |
| title | Hormonal contraception alters vaginal microbiota and cytokines in South African adolescents in a randomized trial |
| title_full | Hormonal contraception alters vaginal microbiota and cytokines in South African adolescents in a randomized trial |
| title_fullStr | Hormonal contraception alters vaginal microbiota and cytokines in South African adolescents in a randomized trial |
| title_full_unstemmed | Hormonal contraception alters vaginal microbiota and cytokines in South African adolescents in a randomized trial |
| title_short | Hormonal contraception alters vaginal microbiota and cytokines in South African adolescents in a randomized trial |
| title_sort | hormonal contraception alters vaginal microbiota and cytokines in south african adolescents in a randomized trial |
| url | https://doi.org/10.1038/s41467-020-19382-9 |
| work_keys_str_mv | AT christinaballe hormonalcontraceptionaltersvaginalmicrobiotaandcytokinesinsouthafricanadolescentsinarandomizedtrial AT iyaloonkonstantinus hormonalcontraceptionaltersvaginalmicrobiotaandcytokinesinsouthafricanadolescentsinarandomizedtrial AT shameemzjaumdally hormonalcontraceptionaltersvaginalmicrobiotaandcytokinesinsouthafricanadolescentsinarandomizedtrial AT enockhavyarimana hormonalcontraceptionaltersvaginalmicrobiotaandcytokinesinsouthafricanadolescentsinarandomizedtrial AT katielennard hormonalcontraceptionaltersvaginalmicrobiotaandcytokinesinsouthafricanadolescentsinarandomizedtrial AT rachelesra hormonalcontraceptionaltersvaginalmicrobiotaandcytokinesinsouthafricanadolescentsinarandomizedtrial AT shaunlbarnabas hormonalcontraceptionaltersvaginalmicrobiotaandcytokinesinsouthafricanadolescentsinarandomizedtrial AT annaursulahappel hormonalcontraceptionaltersvaginalmicrobiotaandcytokinesinsouthafricanadolescentsinarandomizedtrial AT zoemoodie hormonalcontraceptionaltersvaginalmicrobiotaandcytokinesinsouthafricanadolescentsinarandomizedtrial AT katherinegill hormonalcontraceptionaltersvaginalmicrobiotaandcytokinesinsouthafricanadolescentsinarandomizedtrial AT tanyapidwell hormonalcontraceptionaltersvaginalmicrobiotaandcytokinesinsouthafricanadolescentsinarandomizedtrial AT ulaskaraoz hormonalcontraceptionaltersvaginalmicrobiotaandcytokinesinsouthafricanadolescentsinarandomizedtrial AT eoinbrodie hormonalcontraceptionaltersvaginalmicrobiotaandcytokinesinsouthafricanadolescentsinarandomizedtrial AT venessamaseko hormonalcontraceptionaltersvaginalmicrobiotaandcytokinesinsouthafricanadolescentsinarandomizedtrial AT hoyamgamieldien hormonalcontraceptionaltersvaginalmicrobiotaandcytokinesinsouthafricanadolescentsinarandomizedtrial AT stevenebosinger hormonalcontraceptionaltersvaginalmicrobiotaandcytokinesinsouthafricanadolescentsinarandomizedtrial AT landonmyer hormonalcontraceptionaltersvaginalmicrobiotaandcytokinesinsouthafricanadolescentsinarandomizedtrial AT lindagailbekker hormonalcontraceptionaltersvaginalmicrobiotaandcytokinesinsouthafricanadolescentsinarandomizedtrial AT joannspassmore hormonalcontraceptionaltersvaginalmicrobiotaandcytokinesinsouthafricanadolescentsinarandomizedtrial AT heatherbjaspan hormonalcontraceptionaltersvaginalmicrobiotaandcytokinesinsouthafricanadolescentsinarandomizedtrial |